Molecular Basis for the Different Activation Kinetics of the Pacemaker Channels HCN2 and HCN4
نویسندگان
چکیده
منابع مشابه
Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.
In sino-atrial and atrio-ventricular nodal cells, hyperpolarization-activated cyclic nucleotide-gated (HCN) inward current carrying cationic channels, I(f), are expressed that contribute importantly to the diastolic depolarization critical for cardiac pacemaker activity. Although previous studies have demonstrated myocardial expression of both the HCN2 and HCN4 subunits, the specific roles of t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m305318200